The Magic Inkwell
Cat Garza is the man. He's got this inventive, imaginative art style that both references classic comic styles of old, but brings a new twist on it. He has experimented with mashing up music and comics. He's also been making webcomics before we called them webcomics. Scott McCloud pointed to him as a pioneer in this world of 0s and 1s we inhabit (McCloud has consistently linked to cat on his website).
Most recently he's living in Comics Town USA and working on a new comic The Year of the Rat. You can find the Year of the Rat comics at his site The Magic Inkwell and older comics and music at his webcomicsnation site. I caught up with cat in an interview over email this month.